Moses Sithole was born on 17 November 1964 in Vosloorus, a township near Boksburg, in Transvaal Province, now known as Gauteng, South Africa. His early life was difficult. When he was five years old, his father passed away, and shortly after that, his mother abandoned him and his siblings. This left them without parental care. As a result, Moses and his siblings spent the next three years living in an orphanage. In this place, he later claimed that they were mistreated.

During his teenage years, Moses faced legal troubles. He was arrested for rape, which led to him spending seven years in prison. He often talked about how this time in prison changed him and contributed to a darker path in his life. After his release, he expressed that he believed the women he would later harm reminded him of those who had accused him of rape in the past. This difficult childhood and the experience of imprisonment had a significant impact on his life.

Moses Sithole, a South African serial killer, targeted women between July 1994 and November 1995. He was known for his method of luring women under the pretense of offering them jobs with his charity organization, Youth Against Human Abuse. Most of his victims were interviewed for positions with this fake charity. Once they were in remote locations, he would assault, rape, and kill them. He often used their underwear to strangle them.

Sithole's crimes took place in various locations, including Atteridgeville, Boksburg, and Cleveland, around Johannesburg. By 1995, the number of his victims had exceeded thirty, causing panic across the nation. In some cases, he called the families of his victims just to taunt them.

In August 1995, authorities linked him to one of the victims, but he managed to evade capture after they discovered his past conviction for rape. Later that year, he contacted a South African journalist and admitted to being the wanted killer, claiming to have murdered 76 people. He even provided details about where one of the bodies was hidden.

On November 6, 1995, authorities cornered Sithole in Johannesburg. He attacked an officer with a hatchet, prompting police to shoot him. After his arrest, it was discovered that he was HIV positive and also had tuberculosis.

During the trial, evidence from the journalist helped secure his conviction. On December 5, 1997, he received a sentence of 2,410 years in prison, which included 50 years for each of the 38 murders he was convicted of. Additionally, he received sentences for multiple rapes and robberies. The judge mandated that he serve at least 930 years before being eligible for parole. He is currently imprisoned in Mangaung Correctional Centre.