Lowell Edwin Amos was born on January 4, 1943, in Anderson, Indiana. He grew up in a typical American family, but details about his early childhood are limited. As a young man, he moved on to gain a position as a manager at General Motors. His career here helped build a stable life for him.

Lowell had three wives throughout his life. He met his first wife, Saundra, and they married, but their relationship ended with her untimely death in 1979. She was found dead under unclear circumstances, and her passing raised questions. Despite the uncertainty, Lowell received a significant insurance payout after her death.

Following Saundra, he married Carolyn. Their marriage faced challenges, and they had frequent arguments. Eventually, Carolyn ended the relationship and sent Lowell packing. Afterward, he moved in with his mother. Shortly after he did, his mother also fell ill and later died. Like with his first wife, many details surrounding her death were unclear.

Lowell married Roberta next. Their relationship also faced difficulties, and Roberta sought independence by discussing plans to separate from him. This caused tensions between them.

In December 1994, Lowell and Roberta Amos attended a company party at the Atheneum Hotel in Detroit. They went to their suite at 4:30 am. A few hours later, Lowell called Bert Crabtree, a fellow executive from the party. He sounded panicked and said that Roberta had died in an accident. He asked Crabtree and another guest, Daniel Porcasi, to come to his room. After they arrived, Lowell asked Porcasi to take his sport coat. Porcasi later found a small leather case with a syringe and a foul-smelling washcloth inside the coat's pocket. These items disappeared after Lowell reclaimed the coat.

Lowell told police that he and Roberta had used cocaine that night. He claimed that he fell asleep and found Roberta dead when he woke up. There was cocaine on the bed linens, and Roberta's body had a level of cocaine more than fifteen times the lethal amount. An autopsy revealed cocaine inside Roberta's vagina, but none was found outside her body. Police suspected that Lowell had cleaned Roberta's body before calling for help. A forensic scientist discovered lipstick and bite marks on a pillowcase and makeup residue, even though Roberta was not wearing makeup when police arrived.

Investigators could not find enough evidence to charge Lowell immediately. They began to watch him and looked into his past. Shortly after Roberta's death, Lowell spent over $1,000 on dining and drinks with two women. Reports came in from other women who claimed that they thought Lowell had drugged them before sex.

The investigation revealed that Lowell's first wife, Saundra, died under suspicious conditions in 1979. She was found dead in their bathroom. Lowell had told police that she mixed wine with a sedative, collapsed, and hit her head. The cause of her death was ruled as indeterminate, and Lowell received $350,000 from insurance. After Saundra's death, Lowell married Carolyn. Friends said they often argued about the life insurance policies Lowell had taken out on her. In 1988, Carolyn kicked him out, and he moved in with his mother. Shortly after, his mother fell ill and was hospitalized. She died days later, and Lowell received over $1 million from her estate.

Lowell later moved back in with Carolyn. Nine months after reconciling, she was found dead next to a full bathtub. Lowell claimed he had taken her a glass of wine, which was later found rinsed and in the dishwasher. He received $800,000 in insurance after Carolyn's death.

Due to changes in Michigan law, evidence from the previous deaths was allowed in Lowell's trial for Roberta's murder. Prosecutors argued he lacked a financial motive for killing Roberta but suggested that he couldn't handle the end of their marriage. They claimed he gave her wine mixed with crushed sedatives, injected cocaine into her body, and smothered her when she convulsed.

On October 24, 1996, Lowell was convicted of premeditated murder and sentenced to life in prison without parole on November 4. He served his sentence at the Lakeland Correctional Facility in Michigan. Charges were never filed regarding the deaths of his other wives and mother. In 1998, his appeal was denied. Lowell Amos died in prison on January 5, 2022, a day after his 79th birthday.