Lisa Jo Chamberlin was born on September 30, 1972, in Oregon. She had a difficult childhood that was marked by abuse. Her biological father frequently mistreated her and her mother. When she was about three or four years old, her parents divorced. After the divorce, her mother struggled with alcoholism and bipolar disorder. Unfortunately, she also abused Lisa.

Later, Lisa's mother remarried. Her stepfather was also abusive to Lisa and her stepsister. During her childhood, Lisa faced severe challenges. She was sexually assaulted by her half-brother and also experienced abuse from a school teacher when she was in fourth grade.

As she grew up, Lisa married three times and had three children: two sons and a daughter with each of her partners. One of her partners was abusive. Despite her past, she was often described as a loving mother who cared deeply for her children.

In March 2004, Lisa Jo Chamberlin and her boyfriend, Roger Lee Gillett, were involved in a double murder in Hattiesburg, Mississippi. They had been staying at the home of Gillett's cousin, Vernon Carl Hulett, and his girlfriend, Linda Marie Heintzelman. On March 19, 2004, Hulett and Heintzelman were last seen alive.

The next day, March 20, 2004, both Hulett and Heintzelman were killed. Reports indicated that Gillett was unhappy about being asked to leave Hulett's house. In an effort to rob Hulett and Heintzelman, they ended up murdering them instead. Heintzelman suffered severe violence, which included rape and multiple forms of physical attack. Hulett was also brutally attacked and died from blunt-force injuries.

After the murders, Chamberlin and Gillett dismembered the bodies. They stored the remains in a freezer and loaded them into Hulett's truck. The couple drove the truck to an abandoned farm in Russell County, Kansas. They managed to evade capture for nine days.

On March 29, 2004, police responded to a report of a stolen vehicle. They found the truck and discovered evidence of drug manufacturing at the farm. During the investigation, police uncovered the dismembered body parts in the freezer, leading to the arrest of Chamberlin and Gillett.

Both were charged with capital murder due to the horrific nature of the crimes. The resulting trials found them guilty, and both received death sentences. Chamberlin, diagnosed with psychological issues, was sentenced to death by lethal injection. Gillett initially received the same sentence but later had his death penalty commuted to life without parole.

As of 2025, Lisa Jo Chamberlin remains on death row, continuing to await her execution in Mississippi.