Jeanne Weber was born on October 7, 1874, in a small fishing village in western France. Life was simple in her hometown, but when she was 14 years old, she moved to Paris. In the bustling city, she took on various menial jobs to support herself. Jeanne married in 1893. Her husband struggled with alcoholism, which added stress to their life together.

Jeanne had three children, but tragedy struck in 1905 when two of them died. At that time, she was living in a run-down tenement in Paris with her husband and their seven-year-old son. As the years went by, Jeanne began to drink heavily as well.

On March 2, 1905, Jeanne Weber was babysitting her sister-in-law's two daughters. During her visit, the 18-month-old Georgette suddenly fell ill and died. The doctor noted strange bruises on her neck but did not take further action, allowing Weber to return just a few days later. On March 11, while babysitting again, Weber's care led to the death of two-year-old Suzanne, who was said to have died from unexplained convulsions.

Then, on March 25, Weber was with her brother's seven-year-old daughter, Germaine. The girl choked and showed red marks on her throat but survived the first incident. Unfortunately, she did not survive the next day, with doctors blaming her death on diphtheria. Shortly after, Weber's own son, Marcel, also died under similar circumstances, leading to confusion and suspicion due to the lack of thorough investigation.

On April 5, 1905, Weber hosted two sisters-in-law for dinner while her ten-year-old nephew, Maurice, stayed home with her. When the women returned, they found Maurice gasping for air, his throat covered in bruises, and Weber standing nearby with an alarming expression. This incident led to charges against her, resulting in a trial that began on January 29, 1906. The prosecution claimed she had killed eight children, including all three of her own. Despite the allegations, her attorney, Henri-Robert, managed to secure her acquittal on February 6, 1906.

Fourteen months later, on April 7, 1907, a doctor was called to examine nine-year-old Auguste Bavouzet, who was found dead with bruising on his throat. Initially, his death was attributed to convulsions, but later, it was revealed that Madame Moulinet, the babysitter, was actually Weber. Although she was held for trial, Weber was again declared innocent when a second autopsy changed the cause of death to typhoid.

After this, Weber took a job at a children's hospital under a different name. However, she was caught strangling a child and was dismissed. Following a period of homelessness, she briefly stayed in a mental asylum, where she was deemed sane. She then engaged in prostitution.

On May 8, 1908, after moving to an inn in Commercy, Weber was found strangling the innkeeper's son, Marcel Poirot, using a bloody handkerchief. The boy's father had to physically intervene to stop her.

Charged with murder, Weber was declared insane on October 25, 1908, and was sent to an asylum in Mareville. She was believed to have committed at least ten murders throughout her life. Ten years later, in 1918, Jeanne Weber ended her life by strangling herself.