Desmond Domnique Jennings was born on October 4, 1971, in Tarrant County, Texas, United States.

In October 1993, Desmond Domnique Jennings was involved in a robbery at a drug house in Fort Worth. Jennings, along with John Freeman, Robert Anderson, and two others, took part in a fatal robbery. On December 24, 1993, Jennings and Freeman killed two people in a house also located in Fort Worth. Just days later, on December 27, 1993, Jennings and Freeman entered another house in Fort Worth.

Inside this house, when Sylvester Walton, aged 44, asked what they wanted, Jennings shot him in the face, killing him. As they went further into the house, they found Wonda Matthews, aged 27, getting up from a bed. Jennings shot her in the head. Afterward, he returned to Walton's body to check for valuables and stole a pouch. As Jennings and Freeman were leaving, Jennings heard Matthews making sounds, so he went back and shot her again.

A few days later, Freeman was arrested while driving a car that matched a report about a robbery. Police found a loaded .32-caliber handgun in the car’s trunk. Ballistics testing linked bullets from this gun to those found in the bodies of Walton and Matthews. In 1995, Jennings was convicted of two counts of capital murder for the killings of Walton and Matthews and was sentenced to death. Freeman received a 30-year sentence for his role in the crimes.

Jennings was executed by lethal injection on November 16, 1999. He chose not to have a last meal. On the day of the execution, he warned prison guards that he would resist. When he refused to leave his cell, prison officials had to use pepper spray to incapacitate him. At the time of his execution, Jennings fought again and needed to be forcibly removed from his holding cell by a team of five officers. This was the first time in Texas, since the death penalty was reinstated in the 1970s, that officials had to use force on a death row inmate. When asked if he had a last statement, Jennings replied, "No, I do not." He was pronounced dead at 6:22 PM.