Brenda Evers Andrew was born on December 16, 1963, in Oklahoma County, Oklahoma. She grew up in a Christian home in Enid, Oklahoma. Her family was known for being devout and enjoyed spending time together. Brenda was a good student and always earned above-average grades in school. Friends described her as quiet and shy. She spent much of her free time at church and enjoyed helping others. In junior high, she became a baton twirler, but she did not participate in the parties that many of her classmates attended, as she did not smoke or drink.

Brenda met Rob Andrew while he was attending Oklahoma State University. She was a high school senior at the time, and they began dating. After he graduated, she transferred to OSU to be closer to him. They married on June 2, 1984. The couple moved to Texas when Rob accepted a job, but in a few years, they returned to Oklahoma City. Brenda became a stay-at-home mom after the birth of their first child, Tricity, on December 23, 1990. They had a second child, Parker, four years later.

By the time Brenda turned 40, her marriage was facing many troubles. Friends said that Brenda displayed verbal abuse towards Rob, often saying she hated him. This led her to begin extramarital affairs. She had relationships with several men, one being a friend's husband, Rick Nunley, and another, James Higgins, who worked at a grocery store.

Brenda met James Pavatt while they both taught Sunday school at their church. Pavatt was also a life insurance agent and helped Rob secure a large insurance policy, naming Brenda as the sole beneficiary. During this time, Brenda and Pavatt started an affair. The couple's marriage deteriorated further, leading Brenda to file for divorce in late September 2001.

In November 2001, the situation escalated when Rob Andrew was shot at their home. Brenda was involved in a plan that ultimately led to Rob's death. After the incident, Brenda and her children fled to Mexico with Pavatt. They were later arrested when attempting to return to the United States.

In November 2001, Brenda Andrew called 911, claiming that two gunmen had shot her husband, Rob Andrew, and wounded her in their garage. Rob had come to pick up their children, but during the visit, Brenda asked him to help fix the furnace. As he bent down to light the pilot light, James Pavatt, Brenda's lover and co-conspirator, shot Rob with a shotgun. Brenda then took the gun and shot Rob again. To cover her involvement, she shot herself in the arm with a .22 caliber handgun.

Initially, Brenda told police that they were attacked by masked intruders. However, investigators quickly found evidence suggesting otherwise. Brenda had been having an affair with Pavatt, a fellow church member and insurance salesman. Just before Rob's murder, he had taken out an $800,000 life insurance policy, naming Brenda as the beneficiary. Friends of Rob reported that he felt unsafe and suspected Brenda's motives.

After the murder, Brenda and Pavatt fled to Mexico, taking the couple's two children with them. They were apprehended after three months while trying to re-enter the United States. During the trials, prosecutors argued that Brenda conspired with Pavatt to kill Rob for the insurance money. Evidence showed that they had tampered with Rob's car prior to the shooting, attempting to create dangerous situations for him.

Brenda was sentenced to death in September 2004, and she remains on death row as the only woman in Oklahoma facing execution. Her case drew significant media attention and raised questions about her motives and her alleged involvement in orchestrating her husband’s murder. Despite her claims of innocence and intentions to appeal her conviction, the courts upheld the decision based on the evidence presented.