Adolfo de Jesús Constanzo was born on November 1, 1962, in Miami, Florida. His mother, Delia Aurora González, was a Cuban immigrant who had him when she was only 15 years old. Delia had three children, each from different fathers. After her first husband died, she moved to San Juan, Puerto Rico, where she remarried. Constanzo was baptized as a Catholic and even served as an altar boy during his early life. He also traveled to Haiti with his mother to learn about Vodou, which was part of their cultural exploration.

In 1972, Constanzo's family returned to Miami. Shortly after their return, his stepfather died, which left them with some money. As a teenager, Constanzo became an apprentice to a local sorcerer. He started to explore a religion called Palo Mayombe, which included animal sacrifices. Delia remarried again, and her new husband was involved in both the Palo Mayombe religion and drug dealing. Constanzo and his mother had several run-ins with the law, facing arrests for theft, vandalism, and shoplifting. He finished high school but was expelled from a prep school during his education.

When he became an adult, Constanzo moved to Mexico City. There, he met three men who would become his followers: Martín Quintana, Jorge Montes, and Omar Orea. Together, they began a business that involved casting spells and performing rituals that included expensive animal sacrifices. Their clientele often consisted of drug dealers and hitmen, who were drawn to the violent aspects of Constanzo's practices. He also gained the attention of wealthy members of Mexican society, including corrupt police officers, which connected him to powerful drug cartels in the area.

Constanzo's practices took a darker turn when he began raiding graveyards for human bones. He believed that the power of his religion could be amplified by using live sacrifices instead of just bones. This belief led him to a series of increasingly violent actions that would shape his notorious reputation in the years to come.

Adolfo de Jesús Constanzo believed that his magical practices were powerful. He asked to become a business partner with the Calzada family, a well-known drug family. When they refused him, seven members of that family vanished. Subsequently, their bodies were found, mutilated and missing various body parts.

Constanzo then connected with another drug cartel led by the Hernandez brothers. He also started a relationship with Sara Aldrete, who became the high priestess of his cult. Constanzo made her second-in-command and instructed her to manage his followers while he was involved in drug trafficking.

In 1988, Constanzo moved to a desert ranch called Rancho Santa Elena. He used the ranch to carry out ritualistic murders and to store large amounts of drugs. On March 13, 1989, Constanzo's followers kidnapped Mark Kilroy, a student from the United States. After taking him to the ranch, Constanzo murdered him. The police later found evidence linking Constanzo to Kilroy's death, along with the remains of many other victims.

After fleeing to Mexico City, Constanzo and his followers were discovered during a police call about an unrelated issue. When police approached, Constanzo fired a machine gun. Realizing he was cornered, he ordered one of his followers to shoot him and another member. Both Constanzo and his companion died before police could arrest them. Several of his followers were captured and charged with various crimes, including murder and drug trafficking.